2005 诺贝尔医学生理学奖


         10月3日，瑞典卡罗林斯卡医学院宣布，把2005年诺贝尔生理学或医学奖授予澳大利亚科学家Barry J. Marshall和J. Robin Warren，以表彰他们发现了导致胃炎和胃溃疡的细菌-幽门螺杆菌。诺贝尔奖委员会在授奖词中说，由于Barry J. Marshall和J. Robin Warren的发现，使得原本慢性的、经常无药可救的胃溃疡变成了只需抗生素和一些其他药物短期就可治愈的疾病。
         在Marshall和Warren发现这种细菌之前，医学界认为正常胃里细菌是不能存活的。1979年根据活组织切片检查结果，Warren发现50%左右的病人的胃腔下半部分附生着许多微小的、弯曲状的细菌。Warren的发现引来了同行的质疑，但也引起了Marshall的极大兴趣，他们决定联合对取自100个病人的活组织切片进行研究。经过反复试验，Marshall成功地培育出一种当时尚不为人知晓的细菌-后来被命名为幽门螺杆菌。基于试验结果，Marshall和Warren认为，幽门螺杆菌是导致胃炎、十二指肠溃疡或胃溃疡的关键因素。发现这种细菌，使胃炎、十二指肠溃疡或胃溃疡的诊断治疗变得及其简单。目前科学家正在研究幽门螺杆菌与胃癌和一些淋巴肿瘤发病之间的联系。
        CMBI特将两位获奖者背景、相关论文、网络链接资源以及幽门螺杆菌相关的文献等信息汇总于此，以供广大读者了解学习之用。

The Nobel Prize in Physiology or Medicine 2005

"for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease"
 
Richard Axel Linda B. Buck
Barry J. Marshall J. Robin Warren
half 1/2 of the prize half 1/2 of the prize
Australia Australia
NHMRC Helicobacter pylori Research Laboratory, QEII Medical Centre; University of Western Australia
Nedlands, Australia 		Perth, Australia
b. 1951 b. 1937
Curriculum Vitae Curriculum Vitae

Barry J. Marshall's page at the University of Western Australia
Barry J. Marshall's web page
Helicobacter pylori Research Laboratory
The Helicobacter Foundatio

About J. Robin Warren from The Australian Institute of Political Science
Helicobacter pylori Research Laboratory
The Helicobacter Foundation
 
Barry J. Marshall
  • Marshall BJ.The Lasker Awards: celebrating scientific discovery. JAMA. 2005 Sep 21;294(11):1420-1.
  • Windsor HM, Abioye-Kuteyi EA, Leber JM, Morrow SD, Bulsara MK, Marshall BJ.Prevalence of Helicobacter pylori in Indigenous Western Australians: comparison between urban and remote rural populations. Med J Aust. 2005 Mar 7;182(5):210-3.
  • Ho GY, Windsor HM, Snowball B, Marshall BJ.Helicobacter pylori is not the cause of sudden infant death syndrome (SIDS). Am J Gastroenterol. 2001 Dec;96(12):3288-94.
  • Samuels AL, Windsor HM, Ho GY, Goodwin LD, Marshall BJ.Culture of Helicobacter pylori from a gastric string may be an alternative to endoscopic biopsy. J Clin Microbiol. 2000 Jun;38(6):2438-9.
  • Windsor HM, Ho GY, Marshall BJ.Successful recovery of H. pylori from rapid urease tests (CLO tests). Am J Gastroenterol. 1999 Nov;94(11):3181-3.
  • Forbes GM, Glaser ME, Cullen DJ, Warren JR, Christiansen KJ, Marshall BJ, Collins BJ.Duodenal ulcer treated with Helicobacter pylori eradication: seven-year follow-up. Lancet. 1994 Jan 29;343(8892):258-60.
  • Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ, Phillips M, Waters TE, Sanderson CR.Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet. 1988 Dec 24-31;2(8626-8627):1437-42.
  • Goodwin CS, Marshall BJ, Blincow ED, Wilson DH, Blackbourn S, Phillips M.Prevention of nitroimidazole resistance in Campylobacter pylori by coadministration of colloidal bismuth subcitrate: clinical and in vitro studies. J Clin Pathol. 1988 Feb;41(2):207-10.
    • J. Robin Warren
  • Warren JR, Noone JT, Smith BJ, Ruffin R, Frith P, van der Zwaag BJ, Beliakov GV, Frankel HK, McElroy HJ. Automated attention flags in chronic disease care planning. Med J Aust. 2001 Sep 17;175(6):308-12.
  • Warren JR. Gastric pathology associated with Helicobacter pylori. Gastroenterol Clin North Am. 2000 Sep;29(3):705-51. Review.
  • Warren JR, Bolton P. Intelligent split menus for data entry: a simulation study in general practice medicine. Proc AMIA Symp. 1999;:450-4.
  • Warren JR, Posey B, Thornton T, Parang P. Can computer autoacquisition of medical information meet the needs of the future? A feasibility study in direct computation of the fine grained electronic medical record. Proc AMIA Symp. 1999;:445-9.
  • Warren JR, Tyerman SP. Webifying a patient interview support application. Med Inform (Lond). 1998 Jan-Mar;23(1):63-74.
  • Forbes GM, Warren JR, Glaser ME, Cullen DJ, Marshall BJ, Collins BJ. Long-term follow-up of gastric histology after Helicobacter pylori eradication. J Gastroenterol Hepatol. 1996 Jul;11(7):670-3.
  • Forbes GM, Glaser ME, Cullen DJ, Warren JR, Christiansen KJ, Marshall BJ, Collins BJ. Duodenal ulcer treated with Helicobacter pylori eradication: seven-year follow-up. Lancet. 1994 Jan 29;343(8892):258-60.
  • Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ, Phillips M, Waters TE, Sanderson CR. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet. 1988 Dec 24-31;2(8626-8627):1437-42.

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    • Last Modified: 2005-10-04